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Inhalable materials and biologics for lung defence and drug delivery | Nature Reviews Materials

NPs, a distinct subclass of MPs, possess smaller dimensions, a larger surface-to-volume ratio, and greater chemical reactivity than MPs, enhancing their capacity to disrupt metabolism and impair reproduction in animals 15,16

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If you take 1,000mg of a standard powder and only 10% is absorbed, you are only getting 100mg of benefit