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By orchestrating a sustained decrement in circulating low-density lipoprotein cholesterol (LDL-C) concentrations, these agents attenuate lipid-driven endothelial injury, modulate plaque biology, and substantially diminish the incidence of major adverse cardiovascular events across both primary- and secondary-prevention cohorts

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For research designed around four-mechanism approaches, see GLOW vs KLOW and What Is the KLOW Blend