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Its identification as the first selenoenzyme, and the current understanding of its enzymology are discussed in a separate article in this issue (Flohé et al., special issue)

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Since cholesterol is essential for maintaining the integrity of neuronal cell membranes and is involved in myelin formation, neurosteroid production, and synaptic activity [169], dietary changes that may influence these factors, such as the ketogenic diet and others with demonstrated neuroprotective effects, have been explored