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Serum IL-6 levels have also declined after methotrexate treatment in RA patients in some studies [100]

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Unlike full-length α-MSH or synthetic analogues such as Melanotan-I and Melanotan-II (which primarily activate MC1R for pigmentation or MC4R for metabolic effects), KPV's receptor selectivity profile concentrates on MC1R and MC3R in immune cells

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