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Notwithstanding the robust preclinical data, luteolin is impeded by suboptimal bioavailability attributed to inadequate solubility, swift metabolic degradation, and insufficient stability, thereby necessitating sophisticated delivery methodologies such as nanocarriers, liposomal formulations, polymeric nanoparticles, and phospholipid complexes to augment its absorption and penetration into the central nervous system
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In comparison to the recent 2025 literature on the interactions between vitamin D and exercise, this review offers a comprehensive synthesis that both extends and integrates these findings within a broader context of obesity-related health complications
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