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On this note, a study of Pakistani patients with coronary heart disease and Type II diabetes found that the ‘C’ allele was significantly associated with markers of oxidative stress and damage to arterial lining (vascular endothelial dysfunction)
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For instance, the nitric oxide reductase NorB and the cytochrome c’ (CycP) detoxified NO produced by macrophages (Stevanin et al., 2005), while PorB-TLR2 interaction enhances anti-inflammatory IL-10 production (Samarasinghe et al., 2006) and modulates Nf-κB signaling (Oliveira-Nascimento et al., 2012), reprogramming dendritic cells toward a Th2 response (Mukherjee et al., 2016)
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