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[] This epigenetic silencing of MGST1, a mitochondrial detoxifying enzyme, exacerbates mitochondrial dysfunction, including impaired membrane potential, ATP depletion, and cytochrome C release and reduced electron transport chain activity, and promotes ferroptosis characterized by iron overload, lipid peroxidation, and altered expression of acyl-CoA synthetase long chain family member 4 (ACSL4)/glutathione peroxidase 4 (GPX4) in cardiomyocytes

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