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The Effects of Growth Hormone Receptor on Mitochondrial Biogenesis In recent decades, genetically engineered mouse strains ( GHR gene disrupted or knockout mouse) have become vital tools for exploring the various activities of GH and GHR in vivo ( GHR gene mutations, also allows this strain to become a model system to understand the roles of GHR in vivo (Luo et al., 2016)
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