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In addition to calcium-D-glucarate for maintaining a well-sealed estrogen package and curcumin for helping maintain gut lining integrity and microbial balance, probiotics are a sensible choice.52-56 Gut microbiota and sex hormones have a reciprocal relationship, with hormones influencing the type and number of bacteria in the gut, and those bacteria modulating the level of circulating hormones.57,58 One thing to note is that while probiotic supplementation can promote regularity, reduce gut transit time, and help overcome pathogenic bacteria, some probiotics have also shown pro beta-glucuronidase activity.59-61 This can vary among species and strains, and of course, the individual biome of the patient

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Published findings are predominantly preclinical and should not be interpreted as established safety or efficacy in people