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Studies have shown that CP decreased GPX-4 activity, GSH, SLC7A11 and system Xc − , and increased protein expression of ferritin, transferrin receptor-1 (TFR1), ACSL4, free iron level, ROS, 4-hydroxynonenal (4HNE) and malondialdehyde (MDA) in mouse kidney and in the renal HK-2 cell line (Song et al