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Although the exact role of vitamin D in energy production isn’t clear, studies show that the VDR is located in cells of the pancreas, adipose tissue, liver, and cells of skeletal muscle—all organs that play a key role in energy metabolism and nutritional energy balance

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A maior parte da pesquisa experimental é conduzida em sistemas in vitro e modelos animais, particularmente em tecido adiposo, fígado e músculo esquelético, onde a expressão de NNMT e os parâmetros metabólicos podem ser quantificados