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These findings collectively underscore the cross-species and multi-model efficacy of natural products in targeting the TGF-β/Smad pathway, highlighting their promise as therapeutic agents for IPF

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5.3 Therapeutic strategies to enhance antioxidant defense Given the limitations of sperm’s natural antioxidant defenses, therapeutic strategies aimed at enhancing antioxidant capacity are essential for protecting sperm from oxidative stress and improving male fertility (103)