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The lack of efforts to genetically manipulate this parasite is mostly attributed to the absence of long term in vitro culture and a poor availability of molecular tools to genetically manipulate the parasite

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1,2,3 Future directions An in-depth understanding of the CD38 resistance mechanisms, including factors that contribute to the heterogeneity in responses to CD38 antibodies, will help optimize and individualize treatments for patients with MM who have developed CD38 resistance