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The 2017 Squadrito review documents these effects across in vitro, in vivo, and clinical studies of PDRN in wound healing, with the salvage pathway and A2A receptor activation as the central mechanistic finding [18]

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In our present study the administration of PTX exerted beneficial effects against WRS-induced gastric lesions, followed by an increase of gastric blood flow, and finally accompanied by the fall in lipid peroxidation products such as MDA plus 4-HNE concentration and by a potent increase in SOD activity, as well as decrease of plasma IL-1ß and TNFalpha levels