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[23] Leukotrienes in asthma [edit] Leukotrienes contribute to the pathophysiology of asthma, especially in patients with aspirin-exacerbated respiratory disease (AERD), and cause or potentiate the following symptoms: [24] Airflow obstruction Increased secretion of mucus Mucosal accumulation Bronchoconstriction Infiltration of inflammatory cells in the airway wall Role of cysteinyl leukotrienes [edit] Cysteinyl leukotriene receptors CYSLTR1 and CYSLTR2 are present on mast cells, eosinophil, and endothelial cells

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[DOI] [PMC free article] [PubMed] [Google Scholar] Dixit P, Mukherjee PK, Sherkhane PD, Kale SP, Eapen S