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Because normal mammalian development is dependent on DNA methylation, there is enormous interest in assessing the potential for changes in folate intake to modulate DNA methylation both as a biomarker for folate status and as a mechanistic link to developmental disorders and chronic diseases including cancer
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For Ocrevus, days of supply for each infusion was imputed as: min(182 days, [date of next infusion – date of current infusion + 1])
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