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Compound 2a exhibited the most potant inhibitory activity against HDAC10, with IC 50 0 benzamide ( 2g ) Compound 2g was synthesized from 1g (0.10 g, 0.27 mmol, 1 equiv.), hydroxylamine (50 wt % in water, 0.52 mL, 0.26 g, 7.99 mmol, 30 equiv.) and sodium hydroxide (0.04 g, 1.08 mmol, 4.0 equiv) following the general procedure and reaction conditions described above

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While FDA-approved agents demonstrate clinical potential, investigational peptides require rigorous validation through well-designed clinical trials to establish safety and efficacy for healthspan extension