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3.4 Neurogenesis and synaptic plasticity Following a stroke, the brain initiates a complex process of neurogenesis and synaptic plasticity as part of its intrinsic attempt to repair damaged neural circuits and restore lost functions (65, 66)

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TB-500 has been examined in brain injury and neurodegeneration models — with research documenting neuronal cell survival promotion through PI3K/Akt anti-apoptotic signalling, promotion of neurogenesis and oligodendrocyte progenitor migration following white matter injury, and anti-inflammatory effects in the injured CNS