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The increased levels of ROS cause the disruption of the KEAP1–Nrf2 complex and promotion of Nrf2’s translocation to the nucleus, which leads to enhanced expression of antioxidant and detoxification genes, including γGCL, a key enzyme of GSH synthesis [296,297]
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10.1016/j.mam.2013.01.006 [DOI] [PMC free article] [PubMed] [Google Scholar] D’Aiuto L., Di Maio R., Mohan K., Minervini C., Saporiti F., Soreca I., et al
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