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With such tight metal-protein affinities, off-rates to the hydrated state would be so slow as to exceed the lifetimes of proteins before thermodynamic equilibrium is approached: Associative ligand exchange overcomes this limitation
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This may be relevant for people with malabsorption disorders such as Crohn's disease or coeliac disease, though it's important to note that for pernicious anaemia, intramuscular hydroxocobalamin injections remain the first-line treatment in the UK, as recommended by NICE and the British Society for Haematology
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