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How The HPA Axis Affects Mental Health Disorders While scientists study the HPA axis in research settings, this knowledge has practical applications for managing various mental health conditions: Research shows that depression often involves HPA axis changes Understanding this helps explain why depression affects both mood AND physical energy Scientists have found that anxiety disorders often involve an overactive stress response Knowing this helps explain physical symptoms like rapid heartbeat or sweating PTSD: Researchers have discovered that trauma can alter HPA axis function This explains why trauma affects both emotional and physical reactions Understanding your body’s stress response system can help you: Recognize when your body is under too much stress Understand why you might be feeling anxious or depressed Make better choices about managing stress Know when to seek help How Do I Restore My HPA Axis Functioning & Stress Response System