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This work suggests that HGF-MET may also protect from parthanatos, a form of caspase-independent regulated cell death occurring especially in neurons and driven by PARP1 hyperactivation (Galluzzi et al., 2018)
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It is obvious that the failure of antioxidants to seriously modify the injurious actions of oxidants is primarily attributed to their physicochemical characteristics and/or pharmacokinetic properties without excluding other possibilities such as some antioxidants also have prooxidant activities, particularly in the presence of transitional metals [94–97]
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