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A preclinical tool-compound inhibitor of GLS is bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES) 172 , which has been shown to block the growth of cancer cells in vitro , of xenografts in vivo , and to slow tumor growth and prolong survival in genetically engineered mouse models of cancer 151, 173

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