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In addition, Parkinson’s patients are often associated with anxiety, and brain imaging shows reduced gray matter volume in the amygdala and anterior cingulate cortex (ACC), increased functional connectivity (FC) between the amygdala, hippocampus and mPFC, and reduced FC between the lateral Prefrontal Cortex (lPFC), Hip, and Amy ( In summary, the “PFC-Hip-Amy” circuit plays a complex and crucial role in the development of comorbidities associated with NPDs, involving various aspects such as changes in neurotransmitter and gene expression, neuroinflammation, inter-regional information exchange, pain processing, and biopsychosocial pain management

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