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Upstream of this methyl donation, 5-methyltetrahydrofolate (5-MTHF) passes a methyl group to B12 to form methylcobalamin, which in turn converts homocysteine into methionine
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Together, these results suggest that the described amino acid substitutions are not all neutral and they have a functional effect, evidencing a marked inter- and intra-strain variability that can be relevant to determine the differences in GSH production
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