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For instance, ITPD, a metabolite from Radix Aconiti Lateralis, exerts its antitumor effects by activating caspase-3 and caspase-9, inducing Bax/Bcl-2 imbalance, leading to DNA damage and subsequent cell apoptosis (Zhang et al., 2018)
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Cell suspension was centrifuged at 500 g for 5 min at 4 °C
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