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DSIP, Selank, and Epithalon are all peptides below roughly 1,200 daltons but are still cleaved by gastric and intestinal peptidases before absorption

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For instance, NO regulates many enzymes involved in ROS/RNS generation/scavenging such as GSNOR ( S- nitrosylation appears to be critical to GSNO and ONOO - homeostasis as this NO-PTM inhibits GSNOR and PrxII E activities ( - , respectively