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In TRAP1-knockout rats, acetyl-CoA and citrate were increased, and the expression levels of senescence markers (P53, P21, and P16) and H4K12la in VSMCs were decreased, while lipid accumulation, plaque area, and necrotic core size in the aorta were reduced [127]
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Bottle Capsule Count:30 Count
Furthermore, Phe dysmetabolism drives a profound upregulation (approximately 144.6-fold) of downstream metabolites such as hippurate, a recognized pathological biomarker of pre-diabetes (57, 94)
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