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Retatrutide (LY3437943) is Eli Lilly’s experimental triple-agonist drug that activates: GLP-1 (Glucagon-like peptide-1) – reduces appetite and slows digestion GIP (Glucose-dependent insulinotropic peptide) – enhances insulin sensitivity Glucagon receptor – increases fat metabolism and energy expenditure In phase-2 trials, Retatrutide achieved up to 24% body-weight reduction —rivaling or even surpassing bariatric surgery outcomes