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Adverse events led to treatment discontinuation in 4.7% of patients in the selpercatinib group and 26.8% of patients in the control group
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Although treatment with IWR-1 diminished expression of Wnta3a, 5a, β-catenin, and ALP, as well as increased GSK-3β, it would be more rational to see if combination of treatment with IWR-1 and Baicalin could abrogate the induction of growth promoting signals [69]
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